SciAm ran a short bit on Alexander Shulgin, the 'designer' in designer drugs and psychonaut extraordinaire. His best known creation and problem child is MDMA, aka: ecstasy.
Someday somebody will catch up with this guy.
Back in 1988 I had the opportunity to try 2C-B, provided by the man himself. It was a singular experience, all that it's cracked up to be and a bag of chips, with a pickle under the waxpaper.